Fiber optic dissolution is the quicker, more reliable alternative for large or difficult data sets.
Traditional dissolution testing is conducted by manually removing samples from dissolution vessels and bringing the samples to a UV spectrometer or HPLC for testing. With fiber optics, real-time drug release level is determined in-situ or in the vessels without sample removal. The labor-intensive manual sampling procedure is eliminated and the testing procedure is simplified.
It is more economical because consumables for sampling, such as pipettes, syringes, sippers, tubing, and filters, are not needed. In addition, fiber optics can generate more frequent data points and produce a more detailed dissolution profile, which may be beneficial for showing a method’s discriminating ability.
With over 15 years on the market, Pion’s fiber optic technology is the benchmark of reliability. Ten out of ten of the top pharmaceutical companies use Pion’s fiber optic technology for their in-situ UV monitoring needs. Pion’s fiber optic technology is a flexible and reliable tool for determining the rate of release of a drug substance over time.