Are you frustrated by the lack of options for accurately predicting in vivo Bioavailability using in vitro tools?
Do you need a mechanistic understanding of your formulations?
Do you wish there was a robust way to understand the GI transit of APIs?
The inForm from Pion measures the kinetics of dissolution, absorption, controlled supersaturation and precipitation, and accommodates multiple dosage forms and sample types. It provides high quality support for formulation development and reflects industry’s growing interest in dissolution to support in vivo prediction.
Dissolution: Biorelevant, biphasic, automated
Pion inForm bridges the gap between research-based micro-scale dissolution and the compendial world. Innovative methods such as biphasic dissolution and gradient pH adjustments show how a drug would behave under biorelevant conditions. Automation and precision engineering ensure that dissolution experiments are accurate and highly reproducible.
Solubility, controlled supersaturation, precipitation
With many new drugs now requiring solubility enhancement, formulators need ways to characterize supersaturation and precipitation. Pion inForm measures solubility using the CheqSol method; new assays report the extent and duration of supersaturation, precipitation rates and excipient gain factors. Uniquely, concentrations are calculated from measured pH, which eliminates interference by suspended solids. There is also a UV option for controlled supersaturation studies.
A versatile platform
Pion inForm is a versatile platform for automated analysis of solutions. It provides temperature control and high quality stirring, pH measurement and control, ability to add sample and reagents automatically, in-situ UV measurement and the ability to remove aliquots of sample for off-line analysis. Lipolysis assays to study digestion of lipid-based formulations are supported. UV enhancements include multi-component sensing, and Tyndall Rayleigh scattering correction to reduce the effect of suspended solids during dissolution studies.
Use it for
Data to support in vivo studies
- Understanding formulation performance under simulated GI conditions
- The quest for IVIVC
- Make formulation decisions earlier with detailed biorelevant data.
- Investigating solubility enhancement
- Characterizing supersaturation and precipitation
- Comparing dissolution rates of salts
- Optimizing a dosage form in terms of the balance between solubility/dissolution and partitioning
A wide range of assays
- Dissolution in biorelevant media
- Biphasic dissolution with pH control
- Supersaturation, precipitation
- pKa, determination of MECs