A novel in vitro model for subcutaneous injection

Pion Scissor is a new instrument designed to simulate the physiological conditions of the hypodermis, to be used as an in vitro model of the physical behaviour of biopharmaceutical formulations undergoing subcutaneous (SC) injection. Often biopharmaceuticals are formulated under non-physiological conditions with the aim of improving stability and prolonging shelf-life. Biopharmaceuticals intended for SC injection are typically formulated at low pH to mitigate decomposition, and in the presence of various stabilising agents and excipients

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