In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

Dissolution testing is an assay commonly used during the drug product development stage as well as a part of the quality control (QC) testing of the final dosage forms of drug products. Concentration monitoring using in situ fiber optic UV automates the dissolution measurements eliminating uncertainties related to filter selection, timing of volume withdrawal, manual sample handling, etc. More and more drug products are reaching the market as combination of a several APIs making in situ approach difficult while HPLC is time and resource intensive. This study introduces a developed computational method for real time concentration measurements of multiple APIs using in situ fiber optic UV-Vis monitoring.

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