Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

It has been shown1, that disk intrinsic dissolution rate (IDR) can be determined from powder dissolution experiments for BCS class II and IV (low soluble) compounds. This research investigated the applicability of a novel approach for estimating particle size from powder dissolution experiments of very small quantities of compounds. Five model compounds were selected for the study: hydrochlorothiazide, phenazopyridine, 2-naphthoic acid, indomethacin, and dipyridamole (span in solubility 5-911 μg/mL).2

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