Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior in Simulated Intestinal Fluids

It was demonstrated recently that cocrystals of ketoconazole could lead to enhanced aqueous solubility1. However, the absorption of the drug from gastro-intestinal tract (GIT) depends also on dissolution rate and permeability that could be altered by cocrystal constituents. This study was aimed at investigating how cocrystal coformers affect the trans-membrane flux in the in vivo relevant dissolution – permeability setup

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